The legendary band will feature in the MDLBeast Soundstorm 2024 festival that also includes American rapper Eminem and a host of other stars
entertainment9 hours ago
Heart problems? A special diet might help as researchers have found that the popular and controversial ketogenic diet could completely prevent, or even reverse heart failure caused by a metabolic process.
The ketogenic diet is a very low-carb, high-fat diet,
For the findings, published in the journal Nature Metabolism, the research team looked at a metabolic process that seems to be turned down in failing human hearts.
"In an animal model, drastic heart failure in mice was bypassed by switching to high fat or "ketogenic" diets, which could completely prevent, or even reverse the heart failure," said study author Kyle S McCommis from the Saint Louis University in the US.
"Thus, these studies suggest that consumption of higher fat and lower carbohydrate diets may be a nutritional therapeutic intervention to treat heart failure," McCommis added.
According to the researchers, the heart's myocardium requires vast amounts of chemical energy stored in nutrients to fuel cardiac contraction.
To maintain this high metabolic capacity, the heart is flexible and can adapt to altered metabolic fuel supplies during diverse developmental, nutritional, or physiologic conditions.
Impaired flexibility, however, is associated with cardiac dysfunction in conditions including diabetes and heart failure.
The mitochondrial pyruvate carrier (MPC) complex, composed of MPC1 and MPC2, is required for pyruvate import into the mitochondria.
This study demonstrated that MPC expression is decreased in failing human and mouse hearts, and that genetic deletion of the MPC in mice leads to cardiac remodelling and dysfunction.
"Interestingly, this heart failure can be prevented or even reversed by providing a high-fat, low carbohydrate ketogenic diet," McCommis said.
"A 24-hour fast in mice, which is also ketogenic also provided significant improvement in heart remodelling," McCommis added.
The findings showed that diets with higher fat content, but enough carbohydrates to limit ketosis also significantly improved heart failure in mice lacking cardiac MPC expression.
"Our study highlights the potential of dietary interventions to enhance cardiac fat metabolism to prevent or reverse cardiac dysfunction and remodelling in the setting of MPC-deficiency," the authors wrote.
The legendary band will feature in the MDLBeast Soundstorm 2024 festival that also includes American rapper Eminem and a host of other stars
entertainment9 hours ago
The Israeli military said it was looking into the claim
mena9 hours ago
The floating station will feature a modern and contemporary design, inspired by boats and yachts, to facilitate easy access, boarding, and disembarking
uae9 hours ago
Several European nations have said the Israeli premier would be detained if he set foot on their soil, following the ICC arrest warrant against him
world9 hours ago
Regular classes will resume on Wednesday, December 4, announced KHDA
uae10 hours ago
It is the world's longest driverless metro system and the first phase will see three of the six routes become operational
gulf10 hours ago
Kanchana Duangsam sets pace in Female Division, but Anayaa Sood hot on her heels, just one shot behind
sports11 hours ago
Skies will light up in UAE colours at some popular family-friendly spots in the country
uae attractions11 hours ago