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Covid-19: Pfizer, Moderna jabs 80% effective after first shot

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Vials with Pfizer-BioNTech and Moderna vaccine labels. — Reuters

Vials with Pfizer-BioNTech and Moderna vaccine labels. — Reuters

Washington - US study says the risk of infection fell 90 per cent by two weeks after the second shot

Published: Mon 29 Mar 2021, 9:15 PM

Updated: Mon 29 Mar 2021, 10:09 PM

  • By
  • Reuters

Covid-19 vaccines developed by Pfizer Inc with BioNTech SE and Moderna Inc reduced the risk of infection by 80 per cent two weeks or more after the first of two shots, according to data from a real-world US study released on Monday.

The risk of infection fell 90 per cent by two weeks after the second shot, the study of just under 4,000 vaccinated US healthcare personnel and first responders found.

The study by the US Centers for Disease Control and Prevention (CDC) evaluated the vaccines’ ability to protect against infection, including infections that did not cause symptoms. Previous clinical trials by the companies evaluated their vaccine’s efficacy in preventing illness from Covid-19.

The findings from of the real-world use of these messenger RNA (mRNA) vaccines confirm the efficacy demonstrated in the large controlled clinical trials conducted before they received emergency use authorisations from the US Food and Drug Administration.

The study looked at the effectiveness of the mRNA vaccines among 3,950 participants in six states over a 13-week period from December 14, 2020 to March 13, 2021.

“The authorised mRNA Covid-19 vaccines provided early, substantial real-world protection against infection for our nation’s healthcare personnel, first responders, and other frontline essential workers,” CDC Director Rochelle Walensky said in a statement.

The new mRNA technology is a synthetic form of a natural chemical messenger being used to instruct cells to make proteins that mirror part of the novel coronavirus. That teaches the immune system to recognise and attack the actual virus.

The CDC study comes weeks after real-world data from Israel suggested that the Pfizer/BioNTech vaccine was 94 per cent effective in preventing asymptomatic infections.

Some countries, including Britain and Canada, are allowing extended gaps between doses that differ from how the vaccines were tested in clinical trials in order to alleviate supply constraints. In the trials, there was a three-week gap between Pfizer shots and four weeks for the Moderna vaccine.

In Britain, authorities said in January that data supported its decision to move to 12 weeks between the first and second Pfizer/BioNtech shots. Pfizer and its German partner have warned that they had no evidence to prove that.



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