Covid-19: Variant that combines Delta and Omicron identified; dogs sniff out virus with high accuracy

The following is a summary of some recent studies on Covid-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review.

'Deltacron' with genes of Delta and Omicron found

Hybrid versions of the coronavirus that combine genes from the Delta and Omicron variants - dubbed "Deltacron" - have been identified in at least 17 patients in the United States and Europe, researchers said.

Because there have been so few confirmed cases, it is too soon to know whether Deltacron infections will be very transmissible or cause severe disease, said Philippe Colson of IHU Mediterranee Infection in Marseille, France, lead author of a report posted on Tuesday on medRxiv ahead of peer review. His team described three patients in France infected with a version of SARS-CoV-2 that combines the spike protein from an Omicron variant with the "body" of a Delta variant.

Another two unrelated Deltacron infections have been identified in the United States, according to an unpublished report by genetics research company Helix that has been submitted to medRxiv and seen by Reuters.

On virus research bulletin boards, other teams have reported an additional 12 Deltacron infections in Europe since January - all with an Omicron spike and a Delta body.

Genetic recombinations of human coronaviruses have been known to happen when two variants infect the same host cell. "During the SARS-CoV-2 pandemic, two or more variants have co-circulated during same periods of time and in same geographical areas... This created opportunities for recombination between these two variants," said Colson, adding that his team has designed a PCR test that "can quickly test positive samples for the presence of this... virus."

Dogs sniff out coronavirus with high accuracy

New research adds to evidence that trained dogs could help screen crowds to identify people infected with the coronavirus.

At two community screening centers in Paris, 335 volunteers getting traditional PCR tests also provided sweat samples. Overall, 78 people with symptoms and 31 people without symptoms tested positive by PCR. Given the sweat samples to smell, the dogs were 97% accurate at detecting the infected patients, and 100 per cent accurate at detecting infection in the asymptomatic patients, according to a report posted on Tuesday on medRxiv ahead of peer review. They also were 91 per cent accurate at identifying volunteers who were not infected, and 94 per cent accurate at ruling out the infection in people without symptoms.

"Canine testing is non-invasive and provides immediate and reliable results," the authors said. "Further studies will be focused on direct sniffing by dogs to evaluate sniffer dogs for mass pre-test in airports, harbors, railways stations, cultural activities or sporting events."

Future variants-of-concern likely lurk in today's patients

"The virus that replicates in each infected patient is in reality a mixture of slightly different SARS-CoV-2 viruses," and these different viruses account for varying proportions of the full "ensemble," said coauthor Celia Perales of Universidad Autonoma de Madrid. Minority variants in one infected individual can become dominant in someone else, either by chance, or due to a selective advantage related to the presence or absence of drugs, vaccines, or other factors, she said.