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But in excerpts released Wednesday by the White House, Pompeo says that while Tehran has paid "too low a price" for its behavior, Pompeo and Trump are prepared to revise the nuclear deal "to fix its most egregious flaws."
Mindful of Tillerson's reputation as a disengaged leader whose failure to fill critical positions at State alarmed lawmakers, Pompeo acknowledges he has heard firsthand from US diplomats about "how demoralizing it is to have so many vacancies and, frankly, not to feel relevant."
"I'll do my part to end the vacancies," he says in the remarks.
The renewed sense of teamwork "will become the fabric of a State Department culture that finds its swagger once again."
The panel has 11 Republicans and 10 Democrats, and Republican Rand Paul has already expressed his opposition to Pompeo, for the latter's support of the Iraq war and his aggressive posture against Iran.
But Senator Lindsey Graham, a Republican hawk on foreign policy, said Pompeo is "the right guy at the right time" to lead State through a "dangerous" global period.
Trump has gone without a top US diplomat for nearly a month.
In that time he has threatened a trade war with China, blamed Russia and Syria for a suspected chemical attack that killed more than 40 people, and ratcheted up anti-Russia rhetoric on Twitter, including Wednesday's warning that "missiles will be coming" in response to the chemical atrocity in Syria.
And on May 12, exactly one month from the hearing, Trump is to pronounce on the fate of the Iran nuclear deal, a pact Pompeo strenuously opposed in 2015 when he was a member of Congress.
Democrats have said they want to see a new secretary of state considerably more engaged with the agency he oversees.
"He's got a high bar for a lot of us. He's got to commit to ending this assault on the State Department personnel that Tillerson began," Senator Chris Murphy, who is the foreign relations committee, said before Pompeo's excerpts were released.
And with Trump recently appointing hawkish conservative John Bolton as his national security advisor, Murphy said he wanted to scrutinize Pompeo over potential flashpoints like North Korea and Syria.
"A lot of us are worried about the combination of Pompeo and Bolton putting a set of military options on the table for the president that could do real damage to our national security," Murphy said.
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