Common pregnancy complications can slow infant's development in womb: Study

According to a new study led by USC (University of Southern California), gestational diabetes and preeclampsia may be linked to slower biological development in infants.

The research, published on Friday in JAMA Network Open, found that newborns exposed to these two pregnancy complications were biologically younger than their chronologic gestational age. The infants' biological or "epigenetic" age is based on molecular markers in their cells.

The results raise intriguing questions about how common pregnancy complications may affect infants and health outcomes later in childhood. Could they create developmental delays? Could some exposures advance biological age prematurely, even in the womb? What about stressors such as exposure to environmental pollution?

"In ageing research, if your epigenetic 'clock' shows an older age than your chronological age -- due to exposures to various stressors -- that's viewed as bad, as putting people at increased risks for illness," said corresponding author Carrie Breton, a professor of population and public health sciences at the Keck School of Medicine of USC. "We wondered how far back we could take this concept; could we take it to the womb?

"In this case, we found the opposite -- pregnancy complications led to babies with younger biological age. This raises a questions about the impact later in life. This is a fairly new metric and very little is known about it."

For the study, researchers collected DNA samples from 1,801 newborns from 12 cohorts across the U.S. The participants were born between 1998 and 2008 to mothers who had preeclampsia, gestational diabetes or hypertension during pregnancies and compared to pregnancies without any of these complications.

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