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The bus was taking a tour group on the 115 mile (185 kilometre) journey from Aswan to the ancient temples of Abu Simbel, when it ran into the truck parked on the side of a single lane desert road, killing six women and two men.
The Egyptian driver and a guide were also injured in the accident.
Egyptian security officials said the hurt Americans were first transferred to a military hospital for treatment and then 10 of the injured, including two Egyptians, were airlifted to a hospital in Cairo.
An official of Misr Tours which operates the bus service said the accident occurred around dawn while it was still dark shortly after the bus left Aswan. He declined to be identified.
The Great Temple at Abu Simbel, known for its four colossal statues, was built during the reign of Ramses II and was dedicated to the god Amun. It is considered one of the most beautiful ancient monuments in Egypt.
Road accidents are common in Egypt because of bad roads and poor enforcement of traffic rules, and crashes involving tour groups are not uncommon.
Last month, eight foreign tourists were killed when their tour bus lost control and flipped over several times on a winding mountain road near a resort on Egypt’s Red Sea coast, while in October six Belgian tourists were killed in a crash in the south.
Following last month’s accident authorities closed several travel operators after complaints of inadequate safety measures and bad driving.
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