The strike on an apartment killed nine people including a Hezbollah commander, the Syrian Observatory for Human Rights war monitor said
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The UN on Tuesday warned that already low levels of aid trickling into Gaza had dwindled further, with the situation in the besieged north especially "catastrophic".
The warning from UNRWA, the United Nations agency supporting Palestinian refugees, came as Israel said it was opening an additional aid crossing into Gaza on the eve of a US-imposed deadline to improve humanitarian conditions in the war-ravaged territory.
Asked about whether there were signs the situation had improved ahead of Wednesday's deadline, Louise Wateridge, an UNRWA emergencies officer, highlighted that "aid entering the Gaza Strip is at its lowest level in months".
US Secretary of State Antony Blinken and Defence Secretary Lloyd Austin last month cautioned Israel that it had until November 13 to let more aid into Gaza or risk the withholding of some military assistance from the United States, Israel's primary supporter.
The letter was sent weeks before the November 5 US presidential election won by Donald Trump, who has promised to give Israel freer rein.
Speaking to a Geneva media briefing via video-link from Gaza, Wateridge said that "the average for October was 37 trucks a day into the entire Gaza Strip... That is for 2.2 million people".
"Children are dying. People are dying every day," she said, stressing that "people here need everything".
The situation is at its worst in northern Gaza, where a UN-backed assessment at the weekend said that famine was imminent.
No food was permitted to enter besieged northern Gaza for an entire month, Wateridge said, adding that UN requests to access the area have been repeatedly denied.
Wateridge said that testimonies from the north painted "an endlessly horrific" picture that was becoming "more critical" by the hour.
"Hospitals have been bombed, the doctors inform us that they have run out of blood supplies, they have run out of medicine... there are bodies in the streets."
Vowing to stop Hamas militants from regrouping in already-ravaged north Gaza, Israel began a major air and ground assault just over a month ago.
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