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Pope Francis warned the world is on the edge of a "delicate precipice" and buffeted by "winds of war" as he held inter-faith talks with one of Islam's top leaders in Bahrain on Friday.
The 85-year-old pope decried the "opposing blocs" of East and West, a veiled reference to the standoff over Russia's attack on Ukraine, in a speech to religious leaders.
"We continue to find ourselves on the brink of a delicate precipice and we do not want to fall," he told an audience including Bahrain's king and Sheikh Ahmed Al Tayeb, the Grand Imam of Cairo's prestigious Al Azhar mosque.
"A few potentates are caught up in a resolute struggle for partisan interests, reviving obsolete rhetoric, redesigning spheres of influence and opposing blocs," he added.
"We appear to be witnessing a dramatic and childlike scenario: in the garden of humanity, instead of cultivating our surroundings, we are playing instead with fire, missiles and bombs."
Vatican Secretary of State Cardinal Pietro Parolin, who met Russia's Foreign Minister Sergei Lavrov in September, told journalists that there had been "a few small signs" of progress in negotiations with Moscow, warning that peace initiatives should not be "exploited for other goals".
"This meeting has great symbolic importance, both locally and internationally, for promoting peace and peaceful co-existence between different religions and civilisations," said Hala Ramzi Fayez, a Christian and member of Bahrain's parliament.
Al Tayeb, who met with the pope on previous Middle East visits, also called on Friday for talks between Islam's two main branches, Sunni and Shiite, to settle sectarian differences.
Later, the pope addressed 17 members of the Muslim Council of Elders, an international group of Islamic scholars and dignitaries, at the mosque of the Sakhir Royal Palace.
He told them dialogue was "the oxygen of peaceful coexistence".
"In a world that is increasingly wounded and divided, that beneath the surface of globalisation senses anxiety and fear, the great religious traditions must be the heart that unites the members of the body," he said.
The pope, who is using a wheelchair and a walking stick due to long-standing knee problems, began the first papal visit to Bahrain on Thursday.
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